2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W011787
    DPPD 74-31-7 98.02%
    DPPD (N,N′-Diphenyl-p-phenylenediamine) is an orally active polymerization inhibitor and antioxidant with antioxidative activity. DPPD causes reproductive/developmental toxicity in rats. DPPD is widely used in rubber, oils, and feedstuffs, especially for tires in the rubber industry.
    DPPD
  • HY-W016389
    2-Hydroxyfluorene 2443-58-5 99.83%
    2-Hydroxyfluorene (2-OHFLU) is a polycyclic aromatic hydrocarbon metabolite. 2-Hydroxyfluorene is positively associated with cardiovascular disease (CVD) and hyperlipidemia.
    2-Hydroxyfluorene
  • HY-W098348
    N-Methyltaurine 107-68-6
    N-Methyltaurine is a taurine-derived metabolite with a minimum effective concentration of 10 μM for maintaining hamster sperm motility. N-Methyltaurine is the dominant osmolyte of Vespermum virulentum.
    N-Methyltaurine
  • HY-W105739
    18-Hydroxyoctadecanoic acid 3155-42-8 ≥98.0%
    18-Hydroxyoctadecanoic acid (Octadecanoic acid, 18-hydroxy) is an ester product.
    18-Hydroxyoctadecanoic acid
  • HY-W288375
    (R)-3-Hydroxytetradecanoic acid 28715-21-1 ≥98.0%
    (R)-3-Hydroxytetradecanoic acid is an ester product.
    (R)-3-Hydroxytetradecanoic acid
  • HY-W583869
    1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine 6418-95-7 99.0%
    1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine is a phospholipids that contains stearic acid and oleic acid at the sn-1 and sn-2 positions, respectively. It has been used in the generation of lipid nanoparticles (LNPs) for in vitro delivery of mRNA or nuclear-targeted plasmid DNA.
    1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine
  • HY-W674124
    Tripentadecanoin 7370-46-9 98.0%
    Tripentadecanoin (TG(15:0/15:0/15:0)) is a triacylglycerol that contains pentadecanoic acid (HY-W004283) at the sn-1, sn-2, and sn-3 positions.
    Tripentadecanoin
  • HY-Y0337S2
    L-Cysteine-3-13C 201612-57-9 98.5%
    L-Cysteine-3-13C is the 13C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans.
    L-Cysteine-3-13C
  • HY-113123S1
    LysoPC(14:0/0:0)-d7
    LysoPC(14:0/0:0)-d7 (14:0 Lyso PC-d7) is deuterium labeled LysoPC(14:0/0:0). LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect.
    LysoPC(14:0/0:0)-d7
  • HY-N0623S10
    L-Phenylalanine,Indole-15N 84344-22-9 99.6%
    L-Phenylalanine,Indole-15N is the 15N labeled L-Tryptophan[1]. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[2].
    L-Phenylalanine,Indole-15N
  • HY-N0830S10
    Palmitic acid-13C2 86683-25-2 99.54%
    Palmitic acid-13C2 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-13C2
  • HY-W010040R
    4-Hydroxyphenylpyruvic acid (Standard) 156-39-8
    4-​Hydroxyphenylpyruvic acid (Standard) is the analytical standard of 4-​Hydroxyphenylpyruvic acid (HY-W010040). This product is intended for research and analytical applications. 4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-Hydroxyphenylpyruvic acid is a substrate of 4-hydroxyphenylpyruvic acid dioxygenase (HPPA). 4-Hydroxyphenylpyruvic acid can be used in the study of HPD-related diseases, such as type III tyrosinemia and hawkinsinuria.
    4-Hydroxyphenylpyruvic acid (Standard)
  • HY-W012499S
    N-Acetyl-L-methionine-d3 99.87%
    N-Acetyl-L-methionine-d3 is the deuterium labeled N-Acetyl-L-methionine. N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development.
    N-Acetyl-L-methionine-d3
  • HY-W013636S1
    2-Ketoglutaric acid-d4 1381759-60-9
    2-Ketoglutaric acid-d4 (Alpha-Ketoglutaric acid-d4) is the deuterium labeled 2-Ketoglutaric acid (HY-W013636). 2-Ketoglutaric acid Sodium is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM).
    2-Ketoglutaric acid-d4
  • HY-W017018S5
    L-Ornithine-15N2 hydrochloride 360565-59-9 98.90%
    L-Ornithine-15N2 (hydrochloride) is the 15N-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
    L-Ornithine-15N2 hydrochloride
  • HY-W017522S1
    Adipic acid-13C6 942037-55-0 98.0%
    Adipic acid-13C6 (Hexanedioic acid-13C6) is the 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc.
    Adipic acid-13C6
  • HY-15330
    Vitamin D2-d3 1217448-46-8 98.57%
    Vitamin D2-d3 (Ergocalciferol-d3) is the deuterium labeled vitamin D2 (HY-76542), where the C-6 and C-19 protons are replaced by deuterium. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D.
    Vitamin D2-d3
  • HY-76585
    Paricalcitol-d6 2070009-67-3 99.85%
    Paricalcitol-d6 is the deuterium labeled Paricalcitol. Paricalcitol is a agent used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
    Paricalcitol-d6
  • HY-76915
    24, 25-Dihydroxy VD3 40013-87-4 98.55%
    24, 25-Dihydroxy VD3 is a compound closely related to 1,25-dihydroxyvitamin D3 and is the active form of vitamin D3.
    24, 25-Dihydroxy VD3
  • HY-A0020S
    Eldecalcitol-d6 2734920-09-1 99.53%
    Eldecalcitol-d6 is the deuterium labeled Eldecalcitol. Eldecalcitol is an orally active analogue of active vitamin D used in the treatment of osteoporosis.
    Eldecalcitol-d6
Cat. No. Product Name / Synonyms Application Reactivity